(Acts 13:4 - possibly also 14:26 and 15:30,39)  

The seaport that was responsible for the tremendous wealth and expansion of Syrian Antioch was named after Seleucus Nicator I around 300 BCE. The port was founded first, then a trade route established, and finally the planting of a major city. Located a few miles from the mouth of the Orontes River, the flow of goods made their way the fifteen miles to Antioch. There may have been about 30,000 inhabitants during the time of Paulís travels. Paul and Joses Barnabas sailed from Seleucia to Cyprus on their First Mission Journey.